Research Interests

The objectives of our research program are:
- to study the adverse effects of chemicals on living organisms,
- to assess the likelihood that such adverse effects will occur under a given exposure scenario, and
- to elucidate the underlying chemical and biochemical mechanisms which are responsible for the manifest toxicity.

We have been studying the absorption, distribution, metabolism and elimination of environmental pollutants, pesticides, drugs and food contaminants in different mammalian and aquatic species. We have isolated, characterized, and quantified the toxicants and their metabolites in these living organisms using analytical instruments such as gas chromatography, high pressure liquid chromatography, mass spectrometry, etc. We also have developed biologically (physiologically) based disposition models of environmental chemicals in different animal species and have used these computer models to assess the environmental and human health risks of chemical exposure.